Research & Development

Clinical Applicability of Microbiota Sampling – Erasmus

We are proud to announce the publication of a groundbreaking study that highlights the effectiveness of our microbiota sampling techniques. This research, published in Microorganisms journal, showcases our innovative approach to comparing microbial profiles from urine and vaginal samples in women undergoing fertility treatments. The findings underscore our commitment to advancing reproductive health by providing insights that could lead to better fertility treatment outcomes.

Read publication here

UNIKid Stability Study

The German clinic Universitatsklinikum Dusseldorf is conducting a stability study of the vaginal microbiome. The ReceptIVFity test is used to look at the stability of the microbiome in a 4 month period. Read publication here

Probiotic trial (Netherlands)

In Maastricht University Medical Center (the Netherlands) a trial has been approved and is currently starting, this study is investigating the effect of a tailored probiotic formulation for unfavorable ReceptIVFity scoring patients to a more favorable profile. The probiotic group supplied with a probiotic formulation made by ARTPred’s probiotic partner Winclove will be compared with a placebo group and we will monitor changes in both microbiomes and embryo implantation rates.

Microbiome in Chinese women

Together with Prof. Prof. Ernest Ng a pilot trial in Hong-Kong has been started. This trial is running in Queen Mary Hospital and focuses on ethnicity, geography and dietary differences compared to our European populations. Microbiome profiles, predictive models are compared between populations and European cohorts (including European Asian sub cohorts).

Microbiome in Japanese women

Together with Prof. Osamu Ishihara and Dr. Masashi Takamura we have started a pilot trial in Japan. This trial is running in Saitama Medical Center and Saitama Medical University and focuses on ethnicity, geography and dietary differences compared to our European populations. Microbiome profiles, predictive models are compared between populations and European cohorts (including European Asian sub cohorts).

Pilot Shared Decision Making

We are currently running a pilot in Erasmus MC. This is a collaboration with Erasmus MC and CZ healthcare insurer. During the pilot 1000 patients starting an IVF cycle, are offered the ReceptIVFity test. Goal is to study the influence of the test (i.e. having insight in chances of succesful implantation) on the shared decision making process.

MURIM trial

The MURIM study (MUltidisciplinary Research on Implantation failure and repeated Miscarriages) studies the differences in the womb lining of women with implantation failure and women with repeated miscarriages. We suspect that there is no successful implantation in both patient groups due to an imbalance in the receptivity and selectivity of an embryo. The womb lining is reviewed on various aspects. The microbiome is tested using the ReceptIVFity test, and the hormonal profile and immune cells are being mapped. In addition, we examine how these different profiles relate to each other.

Two trials at Zealand University Hospital – Denmark

RIF Trial

In a prospective cohort study we aim to identify possible endometrial factors as a cause of implantation failure in a group of women with recurrent implantation failure(RIF) and controls. The receptIVFity test covers the role of the vaginal microbiome in both cohorts.

MICrobiome INTervention study (MICINT)

In a randomised double blinded placebo controlled trial we wish to investigate the effect of lactobacilli loaded vaginal supplements on a group of women diagnosed with a low or medium profile using the ReceptIVFity test from ARTPred, and to test the sustainability of the effect over one menstrual cycle.